ENTRY       rn00250                     Pathway
NAME        Alanine, aspartate and glutamate metabolism
CLASS       Metabolism; Amino Acid Metabolism
PATHWAY_MAP rn00250  Alanine, aspartate and glutamate metabolism
MODULE      M00017  Glutamate biosynthesis, oxoglutarate => glutamate (glutamate dehydrogenase) [PATH:rn00250]
            M00018  Glutamine biosynthesis, glutamate => glutamine [PATH:rn00250]
            M00019  Glutamate biosynthesis, oxoglutarete => glutamate (glutamate synthase) [PATH:rn00250]
            M00021  Aspartate biosynthesis, oxaloacetate => aspartate [PATH:rn00250]
            M00022  Asparagine biosynthesis, aspartate => asparagine [PATH:rn00250]
            M00026  Alanine biosynthesis, pyruvate => alanine [PATH:rn00250]
            M00038  Glutamine degradation, glutamine => glutamate + NH3 [PATH:rn00250]
            M00040  GABA (gamma-Aminobutyrate) shunt [PATH:rn00250]
            M00044  Aspartate degradation, aspartate => fumarate [PATH:rn00250]
            M00045  Aspartate degradation, aspartate => oxaloacetate [PATH:rn00250]
            M00046  Asparagine degradation, asparagine => aspartate +NH3 [PATH:rn00250]
DISEASE     H00074  Canavan disease (CD)
            H00185  Citrullinemia (CTLN)
            H00197  Adenylosuccinate lyase deficiency
DBLINKS     GO: 0006522 0006531 0006536
REACTION    R00093  L-glutamate:NAD+ oxidoreductase (transaminating)
            R00114  L-Glutamate:NADP+ oxidoreductase (transaminating)
            R00149  Carbon-dioxide:ammonia ligase (ADP-forming,carbamate-phosphorylating)
            R00243  L-Glutamate:NAD+ oxidoreductase (deaminating)
            R00248  L-Glutamate:NADP+ oxidoreductase (deaminating)
            R00253  L-Glutamate:ammonia ligase (ADP-forming)
            R00256  L-Glutamine amidohydrolase
            R00258  L-Alanine:2-oxoglutarate aminotransferase
            R00261  L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)
            R00269  2-Oxoglutaramate amidohydrolase
            R00348  2-Oxosuccinamate amidohydrolase
            R00355  L-Aspartate:2-oxoglutarate aminotransferase
            R00357  L-Aspartic acid:oxygen oxidoreductase (deaminating)
            R00359  D-Aspartate:oxygen oxidoreductase (deaminating)
            R00369  L-Alanine:glyoxylate aminotransferase
            R00396  L-Alanine:NAD+ oxidoreductase (deaminating)
            R00397  L-aspartate 4-carboxy-lyase (L-alanine-forming)
            R00400  L-alanine:oxaloacetate aminotransferase
            R00483  L-aspartate:ammonia ligase (AMP-forming)
            R00484  N-Carbamoyl-L-aspartate amidohydrolase
            R00485  L-Asparagine amidohydrolase
            R00487  Acetyl-CoA:L-aspartate N-acetyltransferase
            R00488  N-Acetyl-L-aspartate amidohydrolase
            R00490  L-Aspartate ammonia-lyase
            R00491  aspartate racemase
            R00575  hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)
            R00576  L-Glutamine:pyruvate aminotransferase
            R00578  L-aspartate:L-glutamine amido-ligase (AMP-forming)
            R00707  (S)-1-pyrroline-5-carboxylate:NAD+ oxidoreductase
            R00708  (S)-1-pyrroline-5-carboxylate:NADP+ oxidoreductase
            R00713  Succinate-semialdehyde:NAD+ oxidoreductase
            R00714  Succinate-semialdehyde:NADP+ oxidoreductase
            R00768  L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
            R01072  5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)
            R01083  N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
            R01086  2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
            R01135  IMP:L-aspartate ligase (GDP-forming)
            R01346  L-Asparagine:2-oxo-acid aminotransferase
            R01397  carbamoyl-phosphate:L-aspartate carbamoyltransferase
            R01648  4-Aminobutanoate:2-oxoglutarate aminotransferase
            R01954  L-Citrulline:L-aspartate ligase (AMP-forming)
COMPOUND    C00014  NH3
            C00022  Pyruvate
            C00025  L-Glutamate
            C00026  2-Oxoglutarate
            C00036  Oxaloacetate
            C00041  L-Alanine
            C00042  Succinate
            C00049  L-Aspartate
            C00064  L-Glutamine
            C00122  Fumarate
            C00152  L-Asparagine
            C00169  Carbamoyl phosphate
            C00232  Succinate semialdehyde
            C00334  4-Aminobutanoate
            C00352  D-Glucosamine 6-phosphate
            C00402  D-Aspartate
            C00438  N-Carbamoyl-L-aspartate
            C00940  2-Oxoglutaramate
            C01042  N-Acetyl-L-aspartate
            C02362  2-Oxosuccinamate
            C03090  5-Phosphoribosylamine
            C03406  N-(L-Arginino)succinate
            C03794  N6-(1,2-Dicarboxyethyl)-AMP
            C03912  (S)-1-Pyrroline-5-carboxylate
REFERENCE   
  AUTHORS   Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  TITLE     [Cellular Functions and Metabolic Maps] (In Japanese)
  JOURNAL   Tokyo Kagaku Dojin (1997)
REFERENCE   PMID:9687539
  AUTHORS   Wu G
  TITLE     Intestinal mucosal amino acid catabolism.
  JOURNAL   J Nutr 128:1249-52 (1998)
REL_PATHWAY rn00010  Glycolysis / Gluconeogenesis
            rn00020  Citrate cycle (TCA cycle)
            rn00230  Purine metabolism
            rn00240  Pyrimidine metabolism
            rn00253  Tetracycline biosynthesis
            rn00260  Glycine, serine and threonine metabolism
            rn00300  Lysine biosynthesis
            rn00330  Arginine and proline metabolism
            rn00340  Histidine metabolism
            rn00410  beta-Alanine metabolism
            rn00460  Cyanoamino acid metabolism
            rn00471  D-Glutamine and D-glutamate metabolism
            rn00473  D-Alanine metabolism
            rn00480  Glutathione metabolism
            rn00650  Butanoate metabolism
            rn00660  C5-Branched dibasic acid metabolism
            rn00760  Nicotinate and nicotinamide metabolism
            rn00770  Pantothenate and CoA biosynthesis
            rn00860  Porphyrin and chlorophyll metabolism
            rn00910  Nitrogen metabolism
KO_PATHWAY  ko00250
///
