ENTRY       b0529             CDS       E.coli
NAME        folD, ads, ECK0522, JW0518
DEFINITION  bifunctional 5,10-methylene-tetrahydrofolate
            dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase
            (EC:1.5.1.5 3.5.4.9)
ORTHOLOGY   K01491  methylenetetrahydrofolate dehydrogenase (NADP+) /
                    methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]
PATHWAY     eco00630  Glyoxylate and dicarboxylate metabolism
            eco00670  One carbon pool by folate
            eco01100  Metabolic pathways
CLASS       Metabolism; Carbohydrate Metabolism; Glyoxylate and dicarboxylate
            metabolism [PATH:eco00630]
            Metabolism; Metabolism of Cofactors and Vitamins; One carbon pool by
            folate [PATH:eco00670]
POSITION    complement(556098..556964)
MOTIF       Pfam: THF_DHG_CYH_C THF_DHG_CYH Amidohydro_1
            PROSITE: THF_DHG_CYH_1 THF_DHG_CYH_2
DBLINKS     NCBI-GI: 16128513
            NCBI-GeneID: 945221
            RegulonDB: B0529
            EcoGene: EG10328
            ECOCYC: EG10328
            UniProt: P24186
STRUCTURE   PDB: 1B0A
AASEQ       288
            MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEE
            VGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDV
            DGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELL
            LAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKV
            VGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE
NTSEQ       867
            atggcagcaaagattattgacggtaaaacgattgcgcagcaggtgcgctctgaagttgct
            caaaaagttcaggcgcgtattgcagccggactgcgggcaccaggactggccgttgtgctg
            gtgggtagtaaccctgcatcgcaaatttatgtcgcaagcaaacgcaaggcttgtgaagaa
            gtcgggttcgtctcccgctcttatgacctcccggaaaccaccagcgaagcggagctgctg
            gagcttatcgatacgctgaatgccgacaacaccatcgatggcattctggttcaactgccg
            ttaccggcgggtattgataacgtcaaagtgctggaacgtattcatccggacaaagacgtg
            gacggtttccatccttacaacgtcggtcgtctgtgccagcgcgcgccgcgtctgcgtccc
            tgcaccccgcgcggtatcgtcacgctgcttgagcgttacaacattgataccttcggcctc
            aacgccgtggtgattggcgcatcgaatatcgttggccgcccgatgagcatggaactgctg
            ctggcaggttgcaccactacagtgactcaccgcttcactaaaaatctgcgtcatcacgta
            gaaaatgccgatctattgatcgttgccgttggcaagccaggctttattcccggtgactgg
            atcaaagaaggcgcaattgtgattgatgtcggcatcaaccgtctggaaaatggcaaagtt
            gtgggcgacgtcgtgtttgaagacgcggctaaacgcgcctcatacattacgcctgttccc
            ggcggcgttggcccgatgacggttgccacgctgattgaaaacacgctacaggcgtgcgtt
            gaatatcatgatccacaggatgagtaa
///
