An SSL handshake failure can occur if an IPCONN is not configured to use SSL in some situations.
This problem results in an ECI_ERR_NO_CICS error.
The IPCONN definition is not configured to use SSL and CICS Transaction Gateway or the resource adapter is running on a different sysplex to CICS (if the Gateway daemon is running on z/OS).
Put the Gateway daemon on the same sysplex as the CICS server.