All affinity regions for program are invalid
A user application specified a program which has no affinity with any of the active regions defined to the Workload Manager.
It is possible to define program affinity to CICS® regions on the Workload Manager, to indicate that a program is defined on a particular CICS region. If using the biasing algorithm, the Workload Manager sends requests only to regions with the correct affinity.
A trace point prior to this one gives the name of the program. Check that the program has affinity with one of the regions defined to the Workload Manager, and that at least one of the CICS regions with affinity is running. The 'cicscli -l' command will indicate if the connection to the CICS server is active.