You can configure your DB2 for z/OS subsystem from Data Studio. During the configuration, you can follow the Configure Subsystem for SQL Tuning wizard to bind the required packages, create EXPLAIN and Query Tuner tables, and grant privileges and access to users. If these objects exist on the subsystem in a different format or version, you see a message. Follow the instructions in the message to migrate them.
To configure a DB2 for z/OS subsystem to tune SQL statements from Data Studio: